Rashid Gedel, 25, and Samuel Dodsworth, 43, have been charged with murder and appeared before Leeds Magistrates' Court.
Ian Watkins, the disgraced frontman of Lostprophets, was fatally injured in an incident at Wakefield Prison on Saturday.
Watkins was jailed in 2013 for a string of child sex offences, including the attempted rape of a baby.
The incident occurred just after 9:30am on Saturday, resulting in Watkins' fatal injuries.
No statement from the defendants has been released.
Author's summary: Two men charged with murdering paedophile singer.