NFL Picks and Predictions for Week 6
The NFL season continues with a highly anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, published on Oct 12, 2025.
Week 6 Predictions
Last week's NFL bold predictions went 2-1, resulting in a gain of +1.17 units overall. Since the start of Week 3, picks in this story are up 2.16 units.
This Week's Bets
Here are 3 bold predictions for this week in the NFL:
- Fading the Colts offense may not be the wisest choice, but there is a case for doing so.
Indianapolis is currently averaging 3.39 points per drive, which would be the most this century if the Colts maintain this pace all season long.
Author's summary: 3 plus-money NFL bets for Week 6.